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PUBLICATIONS


 
Thumbnail image of graphical abstractNucleic Acids Research 
 
 
 

 
Selected Publication:
A. Book chapters
1. Chun-Hua Hsu*. Chapter 14: Structure-based Systems Biology and Drug Design in Cancer Research. Systems Biology: Applications in Cancer-related Research. World Scientific Publishing Company (Dec 30, 2011).
B. Journal Papers
68. Chao-Cheng Cho#, Chia-Yu Chien#, Yi-Chih Chiu, Meng-Hsuan Lin, and Chun- Hua Hsu*. Structural and Biochemical Evidence Supporting Poly ADP-ribosylation in the Bacterium Deinococcus radiodurans. Nature Communications, 2019; 10: 1491.
67. Yu-Jen Wang, Shih-Chin Lee, Chun-Hua Hsu, Yueh-Hsiung Kuo, Chien-Chih Yang, and Fu-Jung Lin*. Antcins, Triterpenoids from Antrodia cinnamomea, as New Agonists for Peroxisome Proliferator-Activated Receptor α. Journal of Food and Drug Analysis. 2019; 27(1): 295-304.
2018
66. An Ning Cheng, Yu-Kang Lo, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, and Alan Yueh-Luen Lee* Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach. EBioMedicine, 2018; 36: 241-251.
65. Ming-Hsien Chien, Wei-Jiunn Lee, Yi-Chieh Yang, Peng Tan, Ke-Fan Pan, Yu- Cheng Liu, Hsiao-Chi Tsai, Chun-Hua Hsu, Yu-Ching Wen, Michael Hsiao, and Kuo-Tai Hua*. N-α-acetyltransferase 10 Protein Promotes Metastasis by Stabilizing Matrix Metalloproteinase-2 Protein in Human Osteosarcomas. Cancer Lett., 2018; 433: 86-98.
64. Ya-Ju Sung, Cheng-Liang Kuo, An Ning Cheng, Chung-Hsing Chen, I-Shou Chang, Shih Sheng Jiang, Chun-Hua Hsu, Jin-Ching Lee, Ting-Yu Kao, Wei-Cheng Fang, Chi-Chen Fan, Yu-Kang Lo, Han-Yu Chou, and Alan Yueh-Luen Lee*. Mitochondrial Lon Sequesters and Stabilizes p53 in the Matrix to Restrain Apoptosis under Oxidative Stress via its Chaperone Activity. Cell Death Dis., 2018; 9:697-713.
63. Tesmine Martin, Yuan-Chao Lou, Chun-Chi Chou, Shu-Yi Wei, Sushant Sadotra, Chao-Cheng Cho, Meng-Hsuan Lin, Jung-Hsiang Tai, Chun-Hua Hsu*, and Chinpan Chen*. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis. Sci. Rep., 2018; 8:5410.
2017
62. Ju-Yi Mao, Han-Wei Li, Shih-Chun Wei, Scott Harroun, Ming-Ying Lee, Hung-Yun Lin, Chih-Yu Chung, Chun-Hua Hsu, Yet-Ran Chen, Han-Jia Lin, and Chih-Ching Huang*. DNA Modulates the Interaction of Genetically Engineered DNA-Binding Proteins and Gold Nanoparticles: Diagnosis of High- Risk HPV Infection. ACS Appl. Mater. Interfaces, 2017; 9(51):44307-44315.
61. Trong-Ming Don, Kun-Ying Lu, Li-Jie Lin, Chun-Hua Hsu, Jui-Yu Wu, and Fwu-Long Mi*. Temperature/pH/Enzyme Triple-Responsive Cationic Protein/PAA-b-PNIPAAm Nanogels for Controlled Anticancer Drug and Photosensitizer Delivery against Multidrug Resistant Breast Cancer Cells. Mol. Pharmaceut., 2017;14(12):4648-4660.

60. Sheng-You Liao, Chi-Wu Chiang, Chun-Hua Hsu, Jayu Jen, Hsueh-Fen Juan, Wu-Wei Lai, and Yi-Ching Wang*. CK1δ/GSK3 beta/FBXW7 alpha Axis Promotes Degradation of the ZNF322A Oncoprotein to Suppress Lung Cancer Progression. Oncogene, 2017; 36(41):5722-5733.
59. Kun-Ying Lu, Rou Li, Chun-Hua Hsu, Cheng-Wei Lin, Shen-Chieh Chou, Min-Lang Tsai*, and Fwu-Long Mi*. Development of a New Type of Multifunctional Fucoidan-based Nanoparticles for Anticancer Drug Delivery. Carbohyd. Polym. 2017; 165:410-420.
58. Po-Jen Wang, Shu-Ting Lin, Shao-Hsuan Liu, Kuang-Ting Kuo, Chun-Hua Hsu, Mark A. Knepper, and Ming-Jiun Yu*. Vasopressin-induced Serine 269 Phosphorylation Reduces Sipa111 (signal-induced proliferation-associated 1 like 1)-mediated Aquaporin-2 Endocytosis. J. Biol. Chem., 2017; 292(19):7984-7993.
57. Yi-Ru Shen, Han-Yu Wang, Yung-Che Kuo, Shih-Chuan Shih, Chun-Hua Hsu, Yet-Ran Chen, Shang-Rung Wu, Chia-Yih Wang*, and Pao-Lin Kuo*. SEPT12 Phosphorylation Results in Loss of the Septin Ring/Sperm Annulus, Defective Sperm Motility and Poor Male Fertility. PLoS Genet., 2017; 13(3):e1006631.
2016
56. Haur Lee, Yu-Lin Su, Bo-Shih Huang, Feng-Tse Hsieh, Ya-Hui Chang, Shiou-Ru Tzeng, Chun-Hua Hsu, Po-Tsang Huang, Kuo-Long Lou, Yeng-Tseng Wang, and Lu-Ping Chow*. Importance of the C-terminal Histidine Residues of Helicobacter pylori GroES for Toll-like Receptor 4 Binding and Interleukin-8 Cytokine Production. Sci. Rep., 2016; 6:37367.
55. Yi-Ping Huang#, Chao-Cheng Cho#, Chi-Fon Chang*, and Chun-Hua Hsu*. NMR Assignments of the Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Biomol. NMR Assign. 2016;10(2):245-248. [PubMed]
54. Chao-Cheng Cho, Meng-Hsuan Lin, Chien-Ying Chuang, and Chun-Hua Hsu*. Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an Efficient ADP-ribose Binding Module: Crystal Structure and Biochemical Studies. J. Biol. Chem. 2016 Mar 4;291(10):4984-4902. [PubMed]
53.Yu-Yung Chang, and Chun-Hua Hsu*. Multiple Conformations of the Loop Region Confers Heat-resistance of SsArd1, a Thermophilic NatA. ChemBioChem, 2016 Feb;17(3):214-217. (Featured on Cover Figure) [PubMed]
52. Han-Lin Liu, Yang-Wei Liu, Tang-Long Shen, Chun-Hua Hsu, and Ya-Chun Chang*. Characterization and Application of a Common Epitope Recognized by a Broad-spectrum C4 Monoclonal Antibody against Capsid Proteins of Plant Potyviruses. Appl. Microbiol. Biotechnol., 2016 Feb;100(4):1853-1869. [PubMed]
2015
51.Yu-Ru Su, Yi-Chin Tsai, Chun-Hua Hsu, An-Chong Chao, Cheng-Wei Lin, Min Lang Tsai, and Fwu-Long Mi*. Effect of Grape Seed Proanthocyanidin−gelatin Colloidal Complexes on Stability and in vitro Digestion of Fish Oil Emulsions. J. Agric. Food Chem., 2015 Nov 25;63(46):10200-10208.  [PubMed]
50. Chun-Hua Hsu*, Chi-Fon Chang, You-Di Liao, Shih-Hsiung Wu, and Chinpan Chen*. Solution Structure and Base Specificity of Cytotoxic RC-RNase 2 from Rana catesbeianaArch. Biochem. Biophys., 2015 Oct 15; 584:70-78. [PubMed]
49. Yu-Lin Su, Jyh-Chin Yang, Fuu Sheu, Chun-Hua Hsu, and Lu-Ping Chow. The C-terminal Disulfide Bonds of Helicobacter pylori GroES are Critical for IL-8 secretion via Toll-like Receptor 4 Dependent Pathway in Gastric Epithelial Cells. J. Immunol., 2015 Apr 15; 194(8):3997-4007. [PubMed]
48. Yu-Yung Chang, and Chun-Hua Hsu*. Structural Basis for Substrate-specific Acetylation of Nalpha-acetyltransferase Ard1 from Sulfolobus solfataricusSci. Rep., 2015 Mar 2; 5: 8673. [PubMed]
2014
47.  Deng-Kai Yang, Lin-Chi Chen*, Ming-Ying Lee, Chun-Hua Hsu, and Chun-Shen Chen. Selection of Aptamers for Fluorescent Detection of Alpha-methylacyl-CoA Racemase by Single-bead SELEX. Biosens. Bioelectron., 2014 Dec 15; 62:106-12. [PubMed]
46.  Kun-Ying Lu, Cheng-Wei Lin, Chun-Hua Hsu, Yi-Cheng Ho, Er-Yuan Chuang, Hsing-Wen Sung*, and Fwu-Long Mi*.FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier. ACS Appl. Mater. Interfaces, 2014 Oct 22; 6(20):18675-89. [PubMed]
45.  Fang-Fang Chen, Yu-Yung Chang, Chao-Cheng Cho, and Chun-Hua Hsu*. Crystallization of the C-terminal Redox Domain of Sulfur Assimilatory Enzyme APR1 form Arabidopsis thalianaActa Crystallogr. Sect. F, 2014 Sep;70(Pt9):1211-14. [PubMed]
44.  Yu-Da Chen, Shih-Hsiung Wu, and Chun-Hua Hsu*. Backbone Resonance Assignment of the alpha Sub-domain from Brevibacillus thermoruberBiomol. NMR Assign., 2014 Oct;8(2):233-6. [PubMed]
43.  Sheng-Chao Wang, Tzong-Huei Lee, Chun-Hua Hsu, Yu-Jia Chang, Man-Shan Chang, Yi-Ching Wang, Yuan-Soon Ho, Wu-Che Wen, Ruo-Kai Lin*. Antroquinonol D, Isolated from Antrodia camphorate, with DNA Demethylation and Anti-cancer Potential. J. Agric. Food Chem., 2014, 62(24):5625-35. [PubMed]
42.  Yi-Jr Chen, Pei-Chien Tsai, Chun-Hua Hsu, and Chia-Yin Lee*. Critical Residues of Class II PHA Synthase for Expanding the Substrate Specificity and Enhancing the Biosynthesis of Polyhydroxyalkanoate. Enzyme Microb. Technol., 2014 Mar 5;56:60-6. [PubMed]
41.  Alan Yueh-Luen Lee#, Yu-Da Chen#, Yu-Yung Chang#, Yu-Ching Lin, Chi-Fon Chang, Shing-Jong Huang, Shih-Hsiung Wu*, and Chun-Hua Hsu*. Structural Basis for DNA-mediated Allosteric Regulation Facilitated by AAA+ Module of Lon Protease. Acta Crystallogr. Sect. D, 2014 Feb;70(Pt 2):218-30. [PubMed]
2013
40.  Chih-Hung Hung#, Tzann-Shun Hwang#, Yu-Yung Chang#, Huei-Ru Luo, Szu-Pei Wu, and Chun-Hua Hsu*. Crystal Structures and Molecular Dynamics Simulations of Thermophilic Malate Dehydrogenase Reveal Critical Loop Motion for Co-substrate Binding. PLoS ONE, 2013 Dec 26;8(12):e83091. [PubMed]
39.  Yen-Wen Lu, Tao Huang, Cheng-Ting Tsai, Yu-Yung Chang, Hung-Wen Li, Chun-Hua Hsu, and Hsiu-Fang Fan*. Using Single-molecule Approaches to study the Archaeal DNA Binding Protein Alba1. Biochemistry, 2013 Nov 5; 52(44):7714-22. [PubMed]
38.  Yu-Yung Chang#, Chih-Hung Hung#, Tzann-Shun Hwang#, and Chun-Hua Hsu*. Cloning, Overexpression, Purification and Crystallization of Malate Dehydrogenase from Thermus thermophilusActa Crystallogr. Sect. F, 2013 Nov;69(pt 11):1249-51. [PubMed]
37.  Chun-Han Su, Chun-Hua Hsu, and Lean-Teik Ng*. Inhibitory Potential of Fatty Acids on Key Enzymes Related to Type 2 Diabetes. Biofactors, 2013 Aug:39(4):415-21. [PubMed]
36.  Yu-Da Chen, Yu-Yung Chang, Shih-Hsiung Wu, and Chun-Hua Hsu*. Crystallography and Preliminary X-ray Diffraction Analysis of the alpha Sub-domain of Lon Protease from Brevibacillus thermoruberActa Crystallogr. Sect. F, 2013 Aug:69(8):899-91. [PubMed]
35.  Hung-Yun Lin, Chi-Yu Shih, Hung-Chun Liu, Jeng Chang, Ying-Lan Chen, Yet-Ran Chen, Han-Tso Lin, Yu-Yung Chang, Chun-Hua Hsu, and Han-Jia Lin*. Identification and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornutumMarine Biotechnology, 2013 Aug:15(4):425-36. [PubMed]
34.   Jiahn-Haur Liao, Yu-Huan Sun, Chun-Hua Hsu, Yu-Ching Lin, Shih-Hsiung Wu*, Chao-Jen Kuo, Chun-Hao Huang, and Shyh-Horng Chiou*. Up-regulation of Neutrophil Activating Protein in Helicobacter pylori under High-salt Stress: Structural and Phylogenetic Comparison with Bacterial Iron-binding Ferritins. Biochmie, 2013 Jun:95(6):1136-45. [PubMed]
33.   Ching-Fang Chien, Johannes Mathieu, Chun-Hua Hsu, Patrick Boyle, Gregory B. Martin, and Nai-Chun Lin*. Nonhost Resistance of Tomato to the Bean Pathgen Pseudomonas syringae pv. syringae B728a is Due to a Defective E3 Ubiquitin Ligase Domain in AvPtoBB728a. Mol. Plant Microbe Interact., 2013 Apr:26(44):387-97. [PubMed]
2012
32.   Chun-Hua Hsu*, Tang-Long Shen, Chi-Fon Chang, Yu-Yung Chang, and Lin-Ya Huang. Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-like Fold with a Redox-active Motif. PLoS ONE. 2012 Dec:7(12):e52292. [PubMed]
31.   I-Chen Peng, Kai-Yin Lo, Chun-Hua Hsu, and Chia-Yin Lee*. Increasing the Storage and Oxidation Stabilities of N-acyl-D-amino Acid Amidohydrolase by Site-directed Mutagenesis of Critical Methionine Residues. Process Biochem. 2012 Dec:47(12):1785-90. [PubMed]
30.   Yu-Ying Chang, Tai-Chih Kuo, Chun-Hua Hsu, Duen-Ren Hou, Yung-His Kao*, and Rong-Nan Huang*. Characterization of the Role of Protein-cysteine Residues in the Binding with Sodium Arsenite. Arch. Toxicol. 2012 Jun: 86(6): 911-22. [PubMed]
29.   Chien-Sheng Chen*, Yi-Ping Yu, Chun-Hua Hsu, Wei Zou, Jim-Ming Fang, and Shih-Hsiung Wu*. Evaluation of the Regioselective Delactonization of Tri-sialic Acid Lactone by In-solution Molecular Dynamics Simulation. Carbohydr. Res. 2012 Jun: 354: 87-93. [PubMed]
2011
28.   Szu-Ta Chen, Yung-Ming Jeng, Cheng-Chi Chang, Hsiu-Hao Chang, Min-Chuan Huang, Hsueh-Fen Juan, Chun-Hua Hsu, Hsinyu Lee, Yung-Feng Liao, Ya-Ling Lee, Wen-Ming Hsu, and Hong-Shiee Lai. Insulin-like Growth Factor II mRNA-binding Protein 3 Expression Predicts Unfavorable Prognosis in Patients with Neuroblastoma.  Cancer Sci. 2011 Dec:102(12):2191-8. [PubMed]
27.   Chun-Hua Hsu, and Andrew H.-J. Wang*. The DNA-recognition Fold of Sso7c4 Suggests a New Member of SpoVT-AbrB Superfamily from Archaea. Nucleic Acids Res. 2011 Aug: 39(15): 6764-74. [PubMed]
2010
26.   Han-Jia Lin*, Yi-Chin Lien, and Chun-Hua Hsu. A high through-put Colorimetric Assay to Characterize the Enzyme Kinetic and Cellular Activity of Spermidine/Spermine N1-Acetyltransferase 1. Anal. Biochem. 2010 Dec15:407(2):226-32. [PubMed]
25.   Han-Ming Wang, Kuo-Chen Cheng, Cheng-Jung Lin, Shu-Wei Hsu, Wei-Cheng Fang, Tai-Feng Hsu, Liang-Cheng Su, Chien-Chih Chiu, Hsueh-Wei Chang, Chun-Hua Hsu, and Alan Yueh-Luen Lee*. Obtusilactone A and (-)-sesamin Induce Apoptosis in Human Lung Cancer Cells via Inhibiting Mitochondrial Lon Protease and Activating DNA Damage Checkpoints. Cancer Sci. 2010 Dec:101(12):2612-20. [PubMed]
24.  Chun-Jiun Yang, Chi-Fon Chang*, Lin-Ya Huang, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu*. Resonance Assignments of Human C35 (C17orf37) Protein, a Novel Tumor Biomarker. Biomol. NMR Assign. 2010 Oct:4(2):191-3. [PubMed]
23. Chun-Hua Hsu*, Yun-Ru Pan, You-Di Liao, Shih-Hsiung Wu, and Chinpan Chen*. NMR and Biophysical Elucidation of Structural Effects on Extra N-terminal Methionine Residue of Recombinant Amphibian RNases from Rana catesbeianJ. Biochem. 2010 Aug:148(2):209-15. [PubMed]
22.  Tung-Ju Hsieh, Tien-Jui Yen, Te-Sheng Lin, Hsun-Tang Chang, Shu-Yun Huang, Chun-Hua Hsu, Lynn Farh, and Nei-Li Chan*. Twisting of the DNA Binding Surface by a Beta-strand-bearing Proline Modulates DNA Gyrase Activity. Nucleic Acids Res. 2010 Jul 1;38(12):4173-4181. [PubMed]
21.  Chun-Hua Hsu*, and Hao-Ping Chen*. Molecular Modeling Studies of the Conserved B12-binding Motif and its Variants from Clostridium tetanomorphum Glutamate Mutase. Protein Pept. Lett. 2010;17(6):759-764. [PubMed]
20.  Hsiao-Hsin Chen, Cuei-Wen Chen, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu*. Preliminary Crystallographic Characterization of the Grb2 SH2 Domain in Complex with a FAK-derived Phosphotyrosyl Peptide. Acta Crystallogr. Sect. F 2010 Feb;66:195-197. [PubMed]
19.  Jiahn-Haur Liao, Yu-Ching Lin, Chiau-Wei Hsu, Alan Yueh-Luen Lee, Tse-An Chen, Chun-Hua Hsu, Jiun-Ly Chir, Kuo-Feng Hua, Tzu-Hua Wu, Li-Jenn Hong, Pei-Wen Yen, Arthur Chiou, and Shih-Hsiung Wu*. Binding and Cleavage of E. coli Hub by the E. coli Lon Protease. Biophys. J. 2010 Jan 6;98(1):129-137. [PubMed]
2009
18.  Yu-Ching Lin, Huai-Cheng Lee, Iren Wang, Chun-Hua Hsu, Jiahn-Haur Liao, Alan Yueh-Luen Lee, Chinpan Chen, and Shih-Hsiung Wu*. DNA-binding Specificity of the Lon Protease a-domain from Brevibacillus thermoruber WR-249. Biochem. Biophys. Res. Commun. 2009 Oct 9;388(1):62-66. [PubMed]
17.   Pei-Yu Chu, Ling-Ya Huang, Chun-Hua Hsu, Chun-Chi Liang, Jun-Lin Guan, Ting-Hsuan Huang, and Tang-Long Shen*. Tyrosine phosphorylation of Grb7 by FAK in the regulation of cell migration, proliferation, and tumorigenesis. J Biol Chem. 2009 Jul 24;284(30):20215-20226. [PubMed]
2008
16.    Hao-Ping Chen*, Huei-Ju Hsu, Fang-Ciao Hsu, Chien-Chen Lai, and Chun-Hua Hsu. The Interactions between Coenzyme B12 Analogs and Adenosylcobalamin Dependent Glutamate Mutase from Clostridium tetanomorphumFEBS J. 2008 Dec;275(23):5960-5968. [PubMed]
15.    Ching-Chang Cho, Ching-Wei Luo, and Chun-Hua Hsu*. Crystallization and Preliminary X-ray Diffraction Analysis of PAT, an Acetyltransferase from Sulfolobus solfataricusActa Crystallogr. Sect. F 2008 Nov; 64:1049-51. [PubMed]
14.    Chun-Hua Hsu*. NMR Studies on Membrane Associated Peptides and Proteins of Influenza Virus. Chemistry (The Chinese Chem. Soc., Taipei) 2008 ; 63(3): 191-7.
13.    Tsui-Chin Huang#, Hsin-Yi Chang#, Chun-Hua Hsu, Wen-Hung Kuo, King-Jen Chang, and Hsueh-Fen Juan*. Targeting Therapy on Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B. J. Proteome Res. 2008 Apr; 7(4): 1433-1444. [PubMed]
2007
12.    Ruo-Kai Lin, Chun-Hua Hsu, and Yi-Ching Wang*. Mithramycin A Inhibits DNA Methyltransferase and Metastasis Potential of Lung Cancer Cell. Anti-cancer Drugs.  2007 Nov; 18(10):1157-64.  [PubMed]
11.     Chien-Sheng Chen, Yi-Ping Yu, Chun-Hua Hsu, Ying-Ta Wu, Wei-Zou, Jim-Min Fang and Shih-Hsiung Wu*. Conformation of Trisialic Acid Lactone: NMR Spectroscopic Analysis and Molecular Dynamics Simulation. Eur. J. Org. Chem. 2007 Aug;22(1):3648-54. [PubMed]
10.     Tsui-Chin Huang, Hsuan-Cheng Huang, Chih-Chin Chang, Hsin-Yi Chang, Chern-Han Ou, Chun-Hua Hsu, Shui-Tein Chen, and Hsueh-Fen Juan*. An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells. FEBS lett. 2007 Jul 24;581(18):3517-22. [PubMed]
2006~ before
9.      Chun-Hua Hsu, Chinpan Chen*, Maou-Lin Jou, Alan Yueh-Luen Lee, Yu-Ching Lin, Yi-Ping Yu, Wei-Ting Huang and Shih-Hsiung Wu*. Structural and DNA-binding Studies on the Bovine Antimicrobial Peptide, Indolicidin: Evidence for Multiple Conformations Involved in Binding to Membranes and DNA. Nucleic Acids Res. 2005 Jul 20;33(13):4053-64. (Featured on Cover Figure)  [PubMed]
8.      Chun-Hua Hsu, Tzu-Ping Ko, Hui-Ming Yu, Tswen-Kei Tang, Shui-Tsung Chen and Andrew H.-J. Wang*. Immunological, Structural and Preliminary X-ray Diffraction Characterizations of the Fusion Core of the SARS-Coronavirus Spike Protein. Biochem. Biophys. Res. Commun. 2004 Nov 12; 324 (2): 761-7.  [PubMed]
7.       Alan Yueh-Luen Lee, Chun-Hua Hsu and Shih-Hsiung Wu*. Functional Domains of Brevibacillus thermoruber Lon Protease for Oligomerization and DNA Binding: Role of N-terminal and sensor and substrate discrimination domains. J. Biol. Chem. 2004 Aug 13;279(33):34903-12.  [PubMed]
6.       Chun-Hua Hsu, You-Di Liao*, Yun-Ru Pan, Lih-Woan Chen, Shih-Hsiung Wu, Ying-Jen Leu and Chinpan Chen*. Solution Structure of the Cytotoxic RNase 4 from Oocytes of Bullfrog Rana catesbeianaJ. Mol. Biol. 2003 Feb 28;326(4):1189-201.  [PubMed]
5.       Chun-Hua Hsu, Shih-Hsiung Wu*, Ding-Kuo Chang and Chinpan Chen*.  Structural Characterizations of Fusion-Peptide Analogs of Influenza Virus Hemagglutinin: Implication of the Necessity of a Helix-Hinge-Helix Motif in Fusion Activity.  J. Biol. Chem. 2002 Jun 21;277(25):22725-33.  [PubMed]
4.      Chinpan Chen*, Chun-Hua Hsu, Ning-Yuan Su, Yu-Ching Lin, Shyh-Horng Chiou* and Shih-Hsiung Wu*. Solution Structure of a Kunitz-Type Chymotrypsin Inhibitor Isolated from the Elapid Snake Bungarus fasciatusJ. Biol. Chem. 2001 Nov 30;276(48):45079-87.  [PubMed]
3.        Chun-Hua Hsu, You-Di Liao, Shih-Hsiung Wu and Chinpan Chen*. 1H, 13C and 15N Resonance Assignments and Secondary Structure of the Cytotoxic Protein RNase 4 from Bullfrog Rana catesbeiana Oocytes. J. Biomol. NMR. 2001 May;20(1):93-4.  [PubMed]
2.       Chun-Hua Hsu, Lih-Woan Chen, You-Di Liao, Shih-Hsiung Wu and Chinpan Chen*. 1H, 15N and 13C Resonance Assignments and Secondary Structure Determination of the RC-RNase 2 from Oocytes of Bullfrog Rana catesbeiana.  J. Biomol. NMR. 2001 Jan;19(1):87-8.  [PubMed]
1.      Chun-Hua Hsu*. Determination of Tertiary Structure of Carbohydrate Molecules. Chemistry (The Chinese Chem. Soc., Taipei) 2000 Jun; 58(2):323-6.
 
B. Conference Papers
63. Der-Shyang Kao, and Chun-Hua Hsu* (2015, Aug). Structural basis for the interaction of UBZ4-type UBD from Spartan with ubiquitin. 2015 ISMAR (International Society of Magnetic Resonance), Shanghai, China.
62. Chun-Hua Hsu* (2015, Aug). Insight into substrate-specific recognition and heat resistance of Nα-acetyltransferase SsArd1 . 14th Internatiinal Congress on Amino Acids and Proteins, Vienna, Austria.
61. Ming-Ying Lee, Chao-Cheng Cho, Yu-Yung Chang, and Chun-Hua Hsu* (2015, May). Structural elucidation of human α-methylacyl-CoA racemase provide insight into its catalytic mechanism and disease-associated mutations. the 20th Biophysics Conference, Taipei, Taiwan.
60. Yi-Yung Lin, Yu-Yung Chang, Fang-Fang Chen, Ming-Yin Lee, and Chun-Hua Hsu* (2015, May). Structural and Functional Studies of Caffeoyl-CoA OMethyltransferase 3 from Arabidopsis thaliana. the 20th Biophysics Conference, Taipei, Taiwan.
59. Yu-Yung Chang, and Chun-Hua Hsu* (2015, May). Insight into substratespecific recognition and heat resistance of Nα-acetyltransferase SsArd1. the 20th Biophysics Conference, Taipei, Taiwan.
58. Fang-Fang Chen, Mei-Chun Tseng, Yet-Ran Chen, and Chun-Hua Hsu* (2014, Aug). Ion-mobility mass spectrometry analysis reveals the quaternary structural and conformational changes for thermal-induced activation of thermophilic SNR. The 20th International Mass Spectrometry Conference, Geneva, Switzerland.
57. Chao-Cheng Cho, Yu-Yung Chang, and Chun-Hua Hsu* (2014, May). Crystal structure of the bacterial type PARG provides insight into molecular mechanism of poly ADP-ribose turnover. the 19th Biophysics Conference, Tainan, Taiwan.
56. Alan Yueh-Luen Lee, Yu-Da Chen, Yu-Yung Chang, Shih-Hsiung Wu and Chun-Hua Hsu* (2013, Dec). Structural Basis for DNA-mediated Allosteric Regulation Facilitated by AAA+ module of Lon Protease. the 12th meeting of Asian Crystallographic Association, Hong-Kong, China.
55. Chao-Cheng Cho, Yu-Yung Chang, and Chun-Hua Hsu* (2013, Jun). Crystal Structure of the Bacterial Type PARG Provides insight into Molecular Mechanism of Poly ADP-ribose Turnover. the 18th Biophysics Conference, Taipei, Taiwan.
54. Chih-Hung Hung, Yu-Yung Chang, Tzann-Shun Hwang, and Chun-Hua Hsu* (2013, Jun). Crystal Structures and Molecular Dynamics Simulations of Thermophilic Malate Dehydrogenase Reveal Critical Loop Motion for Cosubstrate Binding. the 18th Biophysics Conference, Taipei, Taiwan.
53. Chun-Hua Hsu*, Tang-Long Shen, Chi-Fon Chang, Yu-Yung Chang, and Lin-Ya Huang (2013, Jun). Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-like Fold with a Redox-active Motif. the 18th Biophysics Conference, Taipei, Taiwan.
52. Der-Shyang Kao, and Chun-Hua Hsu* (2013, Jun). Structural Basis for the Interaction of UBZ4-type UBD from Spartan with Ubiquitin. the 18th Biophysics Conference, Taipei, Taiwan.
51. Fang-Fang Chen, and Chun-Hua Hsu* (2013, Jun). Structural and biochemical characterizations of APR1 from Arabidopsis thaliana. the 18th Biophysics Conference, Taipei, Taiwan.
50. Ming-Ying Lee, Chih-Hung Hung, Tzann-Shun Hwang, and Chun-Hua Hsu* (2013, Jun). Structural Analysis of α-Galactosidase TtMelA and its Complex with Galactose Reveals Insight into Structural Features and Substrate Binding of GH31 Glycosidase Family. the 18th Biophysics Conference, Taipei, Taiwan.
49. Yi-Ruei Chang, Yu-Yung Chang, Han-Jia Lin, and Chun-Hua Hsu* (2013, Jun). Structures and Functional Analysis of Zebrafish Spermidine/spermine N1- acetyltransferases: Insight into the Substrate Recognition. the 18th Biophysics Conference, Taipei, Taiwan.
48. Yu-Yung Chang, and Chun-Hua Hsu* (2013, Jun). Crystal Structure, Catalytic Mechanism, and Substrate Specificity of Nα-acetyltransferase ssArd1. the 18th Biophysics Conference, Taipei, Taiwan.
47. Chun-Hua Hsu* (2013, May). Molecular Elucidation of a 4Fe-4S Sulfonucleotide Reductase from Sulfolobus solfataricus. the 8th symposium of Asian Biophysics Association, Jeju, Korea. 
46. Chun-Hua Hsu*, Chi-Fon Chang, Tang-Long Shen, Yu-Yung Chang, and Lin-Ya Huang (2012, Aug). Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-like Fold with a Redox-active Motif. XXVth ICMRBS (International Conference on Magnetic Resonance in Biological Systems), Lyon, France.
45. Yu-Yung Chang, Chun-Hua Hsu* (2012, Aug). Structural and Functional Characterizations of the Non-histone-like Chromatin Protein in Archaea. 18th NSRRC Users' Meeting, HsinChu, Taiwan. 
44. Yu-Yung Chang, and Chun-Hua Hsu* (2012, Feb). Molecular basis of the nonmethyl-CpG DNA recognition for CXXC domain of human DNA methyltransferase 1 (DNMT1) . Recent Advances in Biomedicine and Material and TMRS meeting, Taipei, Taiwan.
43. Chih-Hung Hung, Tzann-Shun Hwang, and Chun-Hua Hsu* (2011, Oct). Crystal structure, conformational stability and functional characterization of the thermophilic malate dehydrogenease from Thermus thermophilus HB8. 17th NSRRC Users' Meeting, HsunChu, Taiwan.
42. Yu-Yung Chang, and Chun-Hua Hsu* (2011, Oct). Structural and Functional Characterizations Of The Non-Histone-Like Chromatin Protein In Archaea. 17th NSSRC Users' Meeting, HsinChu, Taiwan.
41. Chih-Hung Hung, Tzann-Shun Hwang, and Chun-Hua Hsu* (2011, May). Structural and Biochemical Characterizations of Thermophilic Malate Dehydrogenease from Thermus thermophilus HB8. The 16th Joints International Conference of Biophysics, HuaLien, Taiwan.
40. I-Shao Chen, Yu-Yung Chang, and Chun-Hua Hsu* (2011, May). Sulfonucleotide Reductase in complexes with AMP and APS reveal the structural snapshots in the catalytic cycle. The 16th Joints International Conference of Biophysics, HuaLien, Taiwan.
39. Yu-Da Chen, Yu-Yung Chang, Shih-Hsiung Wu, and Chun-Hua Hsu* (2011, May). Elucidation of DNA Recognition Mode for the Lon Protease α-domain from Brevibacillus thermoruber WR-249. The 16th Joints International Conference of Biophysics, HuaLien, Taiwan.
38. Yu-Yung Chang, and Chun-Hua Hsu* (2011, May). Molecular basis of the nonmethyl-CpG DNA recognition for CXXC domain of human DNA methyltransferase 1 (DNMT1). The 16th Joints International Conference of Biophysics, HuaLien, Taiwan.
37. Chun-Hua Hsu* (2010, Aug). Solution Structure of the Novel Tumor Biomarker C35 Protein Reveals Redox Activity of a New Thioredoxin-like Family. XXIVth ICMRBS (International Conference on Magnetic Resonance in Biological Systems, Cairns, Australia.
36.   Yu-Yung Chang, and Chun-Hua Hsu 2010. Structural and biochemical analysis in CXXC domain of human DNA methyltransferase 1 (DNMT1). The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
35.   I-Shao Chen, Yu-Yung Chang, and Chun-Hua Hsu 2010. Structural and Functional Characterization of a 4Fe-4S Sulfonucleotide Reductase from Sulfolobus solfataricus. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
34.   Yu-Da Chen, Yu-Ching Lin, Yu-Yung Chang, Shih-Shiung Wu, and Chun-Hua Hsu 2010. Elucidation of DNA Recognition Mode for the Lon Protease a-domain from Brevibacillus thermoruber WR-249. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
33.   Cuei-Wen Chen, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu 2010. Structural Basis of Grb2 SH2 Domain in Complex with a FAK-derived Phosphotyrosyl Peptide. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
32.   Chih-Hung Hung, Chun-Hua Hsu, and Tzann-Shun Hwang 2010. Cloning, Characterization and Structural Study of Malate Dehydrogenase from the Thermophilic Baterium Thermus thermophilus HB8. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
31.   Der-Shyang Kao, Yu-Yung Chang, Re-Fu Hsiao, Cuei-Wen Chen, and Chun-Hua Hsu 2010. Structural and Functional Characterization of Protein a- and e- carbon Acetyltransferases from Sulfolobus solfataricus. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
30.   Yu-Yung Chang, Lin-Ya Huang, Chun-Jiun Yang, Chi-Fon Chang, Tang-Long Shen, and Chun-Hua Hsu 2010. Solution structure of the novel tumor biomarker C35 protein reveals redox activity of a new thioredoxin-like family. The 15th Joints International Conference of Biophysics, May 19~21, Taipei, Taiwan.
29.   Yu-Yung Chang, Chia-Cheng Chou, Yat-Ren Chen, and Chun-Hua Hsu 2009. Structural and Functional Characterization of Protein Acetyltransferase with its Substrates, Alba1 and Alba2 from Sulfolobus solfataricus. The 10th AEARU Workshop on Molecular Biology and Biotechnology, Nov 11~13, Taipei, Taiwan.
28.   Cuei-Wen Chen, Tang-Long Shen, and Chun-Hua Hsu 2009. NMR and CD spectroscopic investigation of FAK phosphotyrosine-peptide bound to Grb2-SH2 Domain. The 10th AEARU Workshop on Molecular Biology and Biotechnology, Nov 11~13, Taipei, Taiwan.
27.   Hiao-Hsin Chen, Cui-Wen Chen, Tang-Long Shen, and Chun-Hua Hsu 2009. Crystal Structure of Grb2-SH2 domain complex with phosphopeptide derived from FAK. The 10th AEARU Workshop on Molecular Biology and Biotechnology, Nov 11~13, Taipei, Taiwan.
26.   Yu-Yung Chang, Chia-Cheng Chou, Yat-Ren Chen, and Chun-Hua Hsu 2009. Structural and Functional Characterization of Protein Acetyltransferase with its Substrates, Alba1 and Alba2 from Sulfolobus solfataricus. The 14th Joints International Conference of Biophysics, Jun 24~27, Tainan, Taiwan.
25.   Cuei-Wen Chen, Tang-Long Shen, and Chun-Hua Hsu 2009. NMR and CD spectroscopic investigation of FAK phosphotyrosine-peptide bound to Grb2-SH2 Domain. The 14th Joints International Conference of Biophysics, Jun 24~27, Tainan, Taiwan.
24.   Hiao-Hsin Chen, Cuei-Wen Chen, Tang-Long Shen, and Chun-Hua Hsu 2009. Crystal Structure of Grb2-SH2 domain complex with phosphopeptide derived from FAK. The 14th Joints International Conference of Biophysics, Jun 24~27, Tainan, Taiwan.
23.    Chun-Hua Hsu 2008. Structural and functional characterization of SsPAT and related proteins. XXIIIrd ICMRBS (International Conference on Magnetic Resonance in Biological Systems). Aug 24~29, San Diego, California, U.S.A.
22.    Chun-Hua Hsu 2008. Structural and functional characterization of the non-histone-like chromatin proteins in archaea. 33rd FEBS Congress and 11th IUBMB Conference, Jun 28~Jul 3, Athens, Greece.
21.   Chun-Hua Hsu 2008. Protein Acetyltransferases and Related Chromatin Proteins in Sulfolobus solfataricus P2: Structural and Chemical Proteomics Approaches. The 13rd Joints Biophysics Conference, May 21~24, Nantou, Taiwan. (Invited Speaker)
20    Yi-Fen Kao, Chun-Hua Hsu 2008. Structural Basis of Neisseria meningitides Ag473 Proteins, the Membrane-associated Proteins with different Tandem Repeats (EAVTEAK). The 13rd Joints Biophysics Conference, May 21~24, Nantou, Taiwan.
19.   Yi-Wei Mak, Shih-Hsiung Wu, and Chun-Hua Hsu 2007. Structural analysis of EcHU, the Histone-like Proteins from Escherichia coli. The 16th triennial ISMAR Conference, Oct 14~19, Kenting, Taiwan.
18.   Yu-Yung  Chang, and Chun-Hua Hsu 2007. Structural analysis of DMAP1 binding domain in human DNA methyltransferase1. The 16th triennial ISMAR Conference, Oct 14~19, Kenting, Taiwan.
17.   Yi-Fen Kao, and Chun-Hua Hsu 2007. Biophysical and structural analysis of the interaction between Oct4 and its transcriptional cofactors.The 16th triennial ISMAR Conference, Oct 14~19, Kenting, Taiwan.
16.    Ching-Chiang Cho, Yi-Wei Mak, Yi-Fen Kao and Chun-Hua Hsu 2007. Structural and functional characterization of SsPAT(Sulfolobus Solfataricus Protein Acetyltransferase). The 16th triennial ISMAR Conference, Oct 14~19, Kenting, Taiwan.
15.    Chun-Hua Hsu, and AndrewH.-J. Wang* 2006. The DNA-recognition fold of Sso7c4 suggests an ancestral role in the evolution of beta-barrel protein family. XXIInd ICMRBS (International Conference on Magnetic Resonance in Biological Systems. Aug 20~25, Gottingen, Germany.
14.     Chun-Hua Hsu, Tzu-Ping Ko, Hui-Ming Yu, Tswen-Kei Tang, Shui-Tsung Chen and Andrew H.-J. Wang. “Structural and Immunological Characterization of the Fusion Core of the SARS-coronavirus Spike Protein” (Aug 23-31, 2005) P-1525, XX Congress of the International Union of Crystallography, Florence, Italy.
13.     Chun-Hua Hsu and Andrew H.-J. Wang. “High-throughput expression of HBV X protein” (Dec 13-17, 2003). The 43th Annual Meeting of American Society for Cell Biology. San Francisco, California, U.S.A.
12.     Chun-Hua Hsu, Jeu-Ming P. Yuann, Andrew H. Wang. “Structure detemination and DNA-binding properties of Sso7C4, a thermostable protein from the archaeon Sulfolobus solfataricus” (2003) Fourth East Asian Biophysics Symposium, Taipei, Taiwan, ROC.
11.     Yuan-Chao Lou, Chun-Hua Hsu, Yun-Ru Pan, Yi-Hsuan Ho, Chung-De Chen, You-Di Liao, Chinpan Chen. “Biophysical Characteristics of Cytotoxic Ribonucleases from Rana catesbeiana” (2003) Fourth East Asian Biophysics Symposium, Taipei, Taiwan, ROC.
10.     Chinpan Chen, Chun-Hua Hsu, Yun-Ru Pan, Lih-Woan Chen, Shih-Hsiung Wu, You-Di Liao. “Biophysical Studies of Cytotoxic Ribonucleases from Rana Catesbeiana” (Aug 25-30,2002) PL354, XXth ICMRBS (International Conference on Magnetic Resonance in Biological Systems), Toronto, Canada.
9.     Chun-Hua Hsu, Shih-Hsiung Wu , Ding-Kwo Chang , Chinpan Chen. “Structural Characterizations of Fusion–Peptide Analogs of Influenza Virus Hemagglutinin: Implication of the Necessity of a Helix-Hinge-Helix Motif in Fusion Activity” (2002) The 8th Biophysical Society Annual Meeting And Frontier Biophysics Symposium, Taiwan, ROC.
8.     Chun-Hua Hsu, Yun-Ru Pan, Lih-Woan Chen, Tung-Liang Lee, You-Di Liao, Shih-siung Wu, Chinpan Chen. “Biophysical Studies of Cytotoxic Ribonucleases from Rana catesbeiana” (2002) The 8th Biophysical Society Annual Meeting And Frontier Biophysics Symposium, Taiwan, ROC.
7.     Chun-Hua Hsu, Shih-Hsiung Wu, Chinpan Chen. “The Structural Study of the Fusion Peptide Analogs of Influenza Virus Hemagglutinin Implicates an a-helix is not sufficient for fusion activity.” (2001) The Seventh Symposium on Recent Advances in Biophysics, Taiwan, ROC.
6.     Chun-Hua Hsu, Shih-Hsiung Wu, Shyh-Horng Chiou, Chinpan Chen. “Solution Structure of Bungarus fasciatus IX, a Kunitz-type chymotrypsin inhibitor” (2001) The Seventh Symposium on Recent Advances in Biophysics, Taiwan, ROC.
5.   Chun-Hua Hsu, Ning-Yuan Su, Cindy C-J Kao, Shih-Hsiung Wu, You-Di Liao, Chinpan Chen. “The Solution structures and Structure-Function Studies of Ribonucleases from Rana catesbeiana (bullfrog) which Possess Different Ribonucleolytic Activity and Cytotoxicity.” (May 22-25, 2000) PA-85, Third East Asian Biophysics Symposium, Kyongju, Korea.
4.   Chun-Hua Hsu, Shih-Hsiung Wu, Shyh-Horng Chiou, Chinpan Chen. “Solution Structure of BF9, A Neurotoxin and Protease Inhibitor from the Venom of Bungarus fasciatus.” (2000) Eighth Symposium on Recent Advances in Cellular and Molecular Biology. Taiwan, ROC.
3.   Chun-Hua Hsu, Shih-Hsiung Wu, Shyh-Horng Chiou, Chinpan Chen. “Solution Structure of BF9, a Neurotoxin and Protease Inhibitor from the Venom of Bungarus fasciatus.” (1999) The Second Taiwan-Japan Nuclear Magnetic Resonance Symposium (TJNMRS). Taiwan, ROC.
2.   Chun-Hua Hsu, Cindy C-J Kao, Chieh-Min Wang, Yi-Ping Yu, Shih-Hsiung Wu, Chinpan Chen. “Conformations of The Fusion Peptide Analogues of Influenza Virus Hemagglutinin HA2.” (1999) The Second Taiwan-Japan Nuclear Magnetic Resonance Symposium (TJNMRS). Taiwan, ROC.
1.   Chun-Hua Hsu, Chinpan Chen, Shyh-Horng Chiou, Shih-Hsiung Wu. “Solution Structure of BF9, Neurotoxin and Protease Inhibitor from the Venom of Bungarus fasciatus” (1998), 1998 Fall Camp, the society    for biochemistry and molecular biology, taipei, Taiwan.
©2006 Hsu Research Group   @ National Taiwan University